Rejuran Hand Injection vs Machine Injection: Which Method to Choose?

When undergoing a skin-regeneration treatment using Rejuran (a polynucleotide-based skin booster), one of the key decisions is how the product is injected. Two common methods used in Korea are manual (hand) injections and machine-assisted injections. Each method has its own advantages and trade-offs. This blog breaks down what you need to know.

What Is Rejuran?

Rejuran is a skin booster product containing highly purified polynucleotides (PN) derived from salmon DNA. The aim is to stimulate fibroblasts, promote collagen and elastin production, improve skin thickness and texture, and support skin regeneration rather than simply volumizing like hyaluronic acid fillers. Cosmetic Connection+2Creatrip+2

Because Rejuran works at a deeper functional level, how it is delivered into the skin — depth, distribution, precision — matters quite a lot.

Hand (Manual) Injection Method

✅ Advantages

• High precision: The doctor controls needle depth, spacing, volume for each point. According to Korean clinic sources, manual delivery ensures “less product loss” and better targeting of dermis. Gangnam Skin Clinic+1
• Customizable: Especially suited for tricky zones (under-eye, nose, scars) where the injector can adapt to anatomy. MayLips
• Potentially stronger effect: Because injection is deeper, more evenly distributed, you may see more notable “embossing” (temporary visible bumps) which signifies correct placement. Gangnam Skin Clinic

⚠️ Trade-offs

• Longer procedure time: Precisely injecting many tiny points takes more time. Gangnam Skin Clinic
• Slightly more discomfort: Because more manual needle insertions, though numbing cream helps. ME CLINIC SEOUL
• Downtime: Might have slight bumps or swelling lasting 24-48 hours.

Machine-Assisted Injection Method

✅ Advantages

• Speed: Machines (injector guns or multi-needle devices) can deliver many micro-injections rapidly across larger surface area. Gangnam Skin Clinic+1
• Less visible immediate trauma: Some patients report less embossing, fewer needle-marks visible immediately. The Lab Clinic+1
• More comfortable for some: Less time per injection, potentially reduced pain in some setups.

⚠️ Trade-offs

• Risk of product loss / sub-optimal depth: Clinics note that machine devices may lead to drug loss between skin/dermis interface if the facial curvature or skin surface is uneven. Gangnam Skin Clinic+1
• Less customization: Machines may not adjust as finely for anatomical variances (thin skin, scars, under-eye hollows) as a skilled injector can.
• May require more sessions or more product for equivalent effect in some cases.

Which Method Should You Choose?

Here’s how to think about which is better for you:

Choose Hand Injection if:

• You have targeted areas of concern: under-eye lines, hollows, acne scars, nose bridge, etc.
• You want maximum precision and are okay with slightly more downtime.
• Your skin texture/volume needs demand nuanced control of depth and spacing.
• You are seeing a highly skilled injector with proven experience in manual PN injections.

Choose Machine Injection if:

• Your goal is overall skin rejuvenation for hydration, texture and global glow (full-face).
• You prefer faster treatment, minimal downtime and are okay with slightly less precision.
• Your skin is relatively uniform (no major anatomical challenges) and you’re comfortable with a slightly more “spread-out” effect rather than highly targeted.

Tips When Getting Rejuran in Korea

• Ask the clinic: Which method will you use (hand vs machine)? What device if machine? What needle gauge/depth if manual?
• Check the injector’s experience with Rejuran, especially manual PN injections.
• Understand the amount of product (cc’s) and number of sessions recommended.
• Ensure after-care instructions: reducing sun/heat, avoiding strenuous exercise, topical care to support recovery.
• For machine method: ask how product loss is minimised and how they handle uneven facial contours.
• For manual method: clarify downtime expectations (bumps, redness) and how to manage them.

Final Thoughts

Both hand and machine-assisted injection methods for Rejuran can deliver excellent results — especially in Seoul’s advanced aesthetic clinics. The best method depends on your skin concerns, budget, downtime tolerance, and the skill of the injector.

• If you want precise correction (scars, under-eye hollows, nose contour), manual injection is often recommended.
• If you are seeking broad skin quality improvement with minimal downtime, the machine method may be more convenient.

When done well, Rejuran delivered by either method can improve skin texture, hydration and resiliency. The key is to go to a clinic where you understand the delivery method, treatment plan, and the provider’s experience, rather than assuming one method is always superior.